CBDV - Cannabidivarin

29/04/2025
Chemical structure of Cannabidivarin (CBDV)

CBDV, or cannabidivarin, is a non-intoxicating cannabinoid that occurs naturally in certain types of Cannabis sativa. It's closely related to CBD, but with a slightly different chemical structure that gives it its own unique characteristics. Although it was first identified in the 1960s, real interest in CBDV has only picked up in more recent years.

From what I’ve seen over time, there’s a growing interest in cannabinoids that go beyond the well-known ones like CBD and THC. CBDV is one of those lesser-known compounds that’s starting to get the attention it deserves—both in research and in conversations around cannabinoid diversity.

Personally, I find it fascinating how these minor cannabinoids are slowly reshaping the way we understand the cannabis plant. As more information becomes available, I’ve found myself wanting to take a closer look at what makes CBDV different—and why it matters.

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Key takeaways

  • CBDV (Cannabidivarin) is a lesser-known phytocannabinoid naturally found in hemp, offering unique characteristics within the cannabinoid family.
  • Unlike THC, CBDV is not associated with psychoactive effects, making it a focus for researchers and product developers exploring non-intoxicating compounds.
  • CBDV’s distinct molecular structure sets it apart from other cannabinoids, prompting continued investigation into its chemical and receptor interactions.
  • Ongoing exploration of CBDV contributes to a deeper scientific understanding of Cannabis sativa and its broader cannabinoid profile.

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Understanding CBDV (Cannabidivarin) and its origins

Cannabidivarin (CBDV) is a naturally occurring cannabinoid found in certain varieties of Cannabis sativa, particularly those with lower levels of THC. It was first identified in the 1960s and has since gained attention for its unique structure and non-intoxicating nature.

While CBDV is structurally similar to CBD, subtle differences in its chemical makeup have made it a subject of growing interest in cannabinoid research. These differences are part of what sets CBDV apart within the broader group of naturally occurring compounds found in the cannabis plant.

What is Cannabis sativa?

Defining CBDV in the context of Cannabis sativa

CBDV is a naturally occurring cannabinoid synthesised by Cannabis sativa. This plant species contains a complex mix of compounds, including terpenoids and flavonoids, which contribute to the wide range of cannabinoids formed through its metabolic pathways.

CBDV emerges as one of the many phytocannabinoids produced under specific genetic and environmental conditions.

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The botanical sources of CBDV

CBDV is predominantly obtained from Cannabis sativa strains selectively cultivated for their cannabinoid profiles. Agricultural practices aimed at enhancing specific phytochemical outputs play a significant role in the production of CBDV.

Observations suggest that the variation in CBDV concentrations is influenced both by the plant’s genetic characteristics and by environmental factors such as soil quality, climate, and cultivation methods.

A 2021 study published in Plants (MDPI) by Kim et al. examined how genetic expression and cultivation practices affect cannabinoid yields, supporting the understanding of CBDV variability.

What is THC (Tetrahydrocannabinol)?

Chemical structure and properties of CBDV

Looking into the CBDV chemical structure shows it's different from other cannabinoids like CBD and THC. Its unique molecular makeup is key to understanding why it doesn't get you high. This is notable for its potential relevance within ongoing scientific research.

Learning about cannabinoid biosynthesis in cannabis plants provides insights into how these compounds are formed. This knowledge supports the scientific exploration of CBDV’s biological interactions. The process is complex but essential for its non-intoxicating effects.

Chemical structure of CBDV

CBDV’s non-psychoactive character makes it a subject of interest in scientific research. Unlike THC, CBDV does not produce euphoria or alteration of perception, which supports its investigation for different applications.

Based on my analysis of available studies, this distinct property positions CBDV as an area of continuing academic focus within cannabinoid science.

Compound Psychoactive property Chemical structure
CBDV Non-psychoactive Shorter chain compared to THC
CBD Non-psychoactive Similar to CBDV, lacks THC potency
THC Psychoactive Longer chain, impacts neurological pathways

What is CBD (cannabidiol)?

Medical research and potential uses of CBDV

Scientific interest in cannabidivarin (CBDV) has grown in recent years, particularly concerning its study within neurological research contexts.

Researchers are investigating CBDV’s interaction with biological systems relevant to neurological studies, focusing on its non-intoxicating properties and the potential relevance of its chemical structure within the context of neurological research.

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Influence of CBDV on neurological function

CBDV is not associated with psychoactive effects, which supports its study without concerns related to altered cognitive perception. Research has investigated its interactions with neurological pathways, examining its presence in studies related to nerve activity.

A paper published in Epilepsia Open (2022) investigated the effects of CBDV on neuronal hyperexcitability, highlighting an area of scientific interest for future research, while noting that further work is needed to understand its potential applications.

Autism and CBDV: Investigating the connections

The connection between CBDV and autism spectrum conditions has attracted growing attention in the scientific community. Investigators are exploring whether CBDV affects neurological pathways involved in behavioural expression.

Early-stage studies, such as those discussed in the Journal of Psychopharmacology (2021), are evaluating the safety and feasibility of CBDV in controlled research environments, with no definitive conclusions regarding its use.

CBDV in epilepsy research

CBDV’s non-psychoactive nature has led to its inclusion in studies investigating seizure-related mechanisms. Preclinical research has examined CBDV in seizure models to support scientific understanding of its interaction with neurological pathways, without the psychoactive impact associated with THC.

Ongoing clinical trials continue to assess its potential, although findings remain at the investigative stage and require further validation before any conclusions can be drawn regarding clinical applications.

Which cannabinoids produce a psychoactive effect?

Exploring the potential side effects and safety profile of CBDV

I can see how important it is to understand the safety profile of CBDV. Cannabinoid research is now focusing on the side effects of cannabinoids like CBDV.

Recent studies, as detailed in a safety assessment report, have started to reveal the complexities of CBDV. The report notes that CBDV's concentration can vary in different batches. This shows the need for strict quality control and a deep understanding of its effects.

As someone committed to responsible research, I believe it is important to carefully assess any observed effects of CBDV in relation to its areas of study. Evaluating observed properties alongside possible risks is essential for maintaining high standards of safety and quality.

Taking a detailed and open approach to assessing CBDV plays an important role in fostering trust with consumers and supporting confidence in the products offered.

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Scientists studying the safety profile and side effects of CBDV.

Research into CBDV remains an evolving field. My focus continues to be directed towards the investigation of its side effect profile and the establishment of robust safety standards. Every phase, from laboratory studies to considerations around product formulation, must meet high expectations for safety and scientific integrity.

How are new cannabinoids being discovered and classified?

CBDV products and their availability

There has been a growing interest in products featuring cannabidivarin (CBDV), driven by increasing consumer curiosity towards cannabinoid-based options. These products are now offered in various formats, often referred to as 'full-spectrum' or 'broad-spectrum', indicating the differing profiles of cannabinoids present.

These formulations typically combine CBDV with other naturally occurring cannabinoids such as cannabidiol (CBD) and trace amounts of delta-9-tetrahydrocannabinol (THC).

Variations in cannabinoid profiles across different products highlight the importance of consistent manufacturing practices and clear, accurate labelling to support consumer confidence.

CBDV products on top of wooden table

Among the available formats, CBDV tinctures have emerged as a commonly selected option, valued for their adaptability and ease of application. The complexity of the cannabis plant presents both challenges and opportunities in product development.

As scientific understanding of CBDV advances, I anticipate that the market will continue to refine standards relating to product quality and cannabinoid composition.

Personal perspective

When I first got involved with cannabinoids, I rarely heard anyone mention CBDV. Even though researchers had identified it years before, it seemed to sit quietly in the background. But as curiosity around the full complexity of the cannabis plant started growing, I found myself paying more attention to this particular compound and what sets it apart.

What keeps drawing me to CBDV is its distinct structure and how it interacts with the body’s endocannabinoid system. It doesn’t produce any intoxicating effects, but its presence opens up all sorts of interesting questions that researchers are still looking into, especially in areas touching on brain function and behaviour.

In developing cannabis-based products, I’ve noticed a gradual, meaningful shift. There’s been a growing recognition that a broader cannabinoid profile can really add something valuable. More and more professionals are starting to treat compounds like CBDV not as background elements, but as genuinely important contributors to the overall picture.

Personally, I think this change is long overdue. Giving proper attention to less familiar cannabinoids like CBDV brings in a fresh perspective. It pushes us closer to more mindful practices and a fuller appreciation of everything this plant has to offer.

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Frequently asked questions

What is CBDV (Cannabidivarin)?

CBDV, or cannabidivarin, is a non-intoxicating cannabinoid naturally occurring in certain cannabis and hemp varieties. It belongs to the same molecular family as CBD (cannabidiol) and is a homolog of it with a shorter side chain.

How does CBDV differ from CBD and THC?

CBDV differs chemically from CBD and THC by having a propyl (three-carbon) side chain instead of a pentyl (five-carbon) chain. This structural variation influences its interaction with receptors and its non-intoxicating properties.

Where does CBDV come from?

CBDV is found primarily in cannabis strains with a higher concentration of CBD, particularly in landrace varieties originating from Asia and Africa. It is naturally synthesised by the cannabis plant during its growth cycle.

Can CBDV get you high?

CBDV does not produce psychoactive effects and is considered non-intoxicating. Unlike THC, it does not activate the CB1 receptor in the brain in a way that alters perception.

How does CBDV compare to CBD and THC?

CBDV shares a similar molecular framework with CBD but differs in its chemical structure. Unlike THC, current research does not associate CBDV with cognitive or euphoric effects.

How is CBDV biosynthesised in cannabis?

CBDV is biosynthesised through the same cannabinoid pathway as CBD, but it begins with divarinolic acid instead of olivetolic acid. The pathway leads to the formation of cannabidivarinic acid (CBDVA), which decarboxylates into CBDV.

Which cannabis strains contain higher levels of CBDV?

Strains such as African landraces and certain hemp varieties, including strains like "Erdpurt" and "CBD Therapy", are known to contain higher levels of CBDV. These strains are typically low in THC and selectively bred for minor cannabinoid content.

What is the difference between CBDV and THCV?

Both CBDV and THCV have a propyl side chain, but THCV is psychoactive at high doses while CBDV is not. THCV interacts with both CB1 and CB2 receptors differently from CBDV, which has a limited affinity for these receptors.

How is cannabis and hemp tested for THC levels?


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Robin Roy Krigslund-Hansen

Robin Roy Krigslund-Hansen

About the author:

Robin Roy Krigslund-Hansen is known for his extensive knowledge and expertise in the fields of CBD and hemp production. With a career spanning over a decade in the cannabis industry, he has dedicated his life to understanding the intricacies of these plants and their potential benefits to human health and the environment. Over the years, Robin has worked tirelessly to promote the full legalisation of hemp in Europe. His fascination with the plant's versatility and potential for sustainable production led him to pursue a career in the field.

More about Robin Roy Krigslund-Hansen

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