Diabetes is a disease that leads to many other diseases. It is responsible for heart failures, strokes, obesity, joint pain, kidney problems and many more. Diabetes occurs when the body as problems in regulating blood sugar levels. The pancreas is the body part that produces a hormone known as insulin which transfers glucose molecules to cells and into cells to form energy. In diabetics, either type 1 or type 2 of diabetes, the body fails to produce insulin or maintain it in a sufficient manner, as a result, unstable glucose levels are found in bloodstream. It has been seen that CB can help in maintaining the production or the functions of insulin.
A research published in 2013 in the American Journal of Medicine, revealed that the cannabis users were diagnosed with lower rates of obesity and diabetes mellitus. The research was done in 5 years and included 4657 men and women, among them 579 were current cannabis users while 1975 were past cannabis users. The fasting blood sugar levels were checked by taking blood samples and to check insulin resistance, HOMA-IR which means homeostasis model assessment of insulin resistance was calculated. Based on the research done, the current users of cannabis were associated with 17% lower HOMA-IR and 16% less fasting blood sugar levels. The study concluded that cannabis use has led to lower fasting insulin levels, as well as lower insulin resistance and a decrease in waist circumference, was also witnessed without any significant side effects.
Another research done by Dr Rafael Mechoulam of the Hebrew University of Jerusalem pointed out the fact that the body’s naturally occurring endocannabinoid receptors were found in nearly all the parts of the body including the immune system, central nervous system and various organs. To his surprise he came to know that these receptors were also highly prevalent in the pancreas which is the organ that produces insulin, in fact, the CB1 receptors were highly available in the pancreas’ islet cells where most of the insulin is produced. The stimuli of the receptors in the cells have a direct association with the production of insulin. The research suggested that CBD may be responsible for maintaining the level’s of insulin by assisting the ECS. This research was so promising that it led the NORML concludes that the “ECS is the most important part of the body to control and regulate its normal functions as well as homeostasis and is responsible for maintaining human health.”
Another important piece of evidence from the same study involves the research done on the rats with infarcts, (dead tissue areas) due to the inadequate blood supply. After treating these rats with CBD, these infarcts were reduced to 30% smaller in size.
In order to understand the role of CBD in connection with diabetes, several types of research have made conclusions about the anti-inflammatory properties of CBD that leads to controlling of diabetes.
As chronic inflammation is one of the major reasons for developing diabetes as well as insulin resistance, it is believed that CBD because of its anti-inflammatory potential can help in regulating blood sugar levels and improving body’s metabolism. The excessive fatty tissues decrease the efficiency of glucose metabolism, which results in high sugar levels in the blood.
The same research of Dr Mechoulam in 2015, concluded that CBD because of its anti-inflammatory qualities can cure diabetes type 1 and type 2 as well.
An improved research done in 2016 revealed that the treatment of CBD decreased inflammation in the pancreas’ microcirculation in mice.
Other studies also learned that inflammation was reduced by using CBD which leads to decreased diabetic conditions. The Autoimmunity Journal published that by injecting 5 mg of CBD every day in mice reduced diabetes. They also mentioned that 60% of the CBD treated mice remained diabetic free for 26 weeks.
Diabetes is also associated with nerve damage, the diabetic people do not feel much in their lower extremities, and often leg’s amputations become vital. This is because of the inadequate supply of blood which damages the nerve tissues and increased the risk of infection. CBD is said to be a neuroprotectant and helps in reducing the size of dead blood areas.
CBD also have a tremendous effect on all the symptoms of diabetes and helps in maintaining overall health. A UK based study which was conducted on diabetes type 2 patients reveals that by the consumption of 100 mg of CBD twice in a day, the patients were met with decreased symptoms of diabetes and witnessed alterations in the insulin sensitivity, body weight, lipid profile, inflammation and cholesterol.
GW pharmaceuticals also researched the effects of CBD and found that CBD leads to better insulin response, reduced blood pressure and greater pancreatic function. Another study revealed that cannabis or CBD users are less likely to become obese, and develop good cholesterol and have improved carbohydrate metabolism.
An Israeli company, ISA scientific have made world collaborations for studying the potentials of CBD and have mentioned that the 1st trial based on dose and safety of CBD has been completed and the 2nd trials are being done on diabetes and chronic pain are in the process. The CEO of ISA scientific also added that CBD can actually reverse, suppress and cure diabetes, unlike other diabetic medications.
Besides the research studies, the various anecdotal evidence is also available regarding the treatments of diabetes by the use of CBD. A patient with type 1 diabetes in California recovered his diabetes by seeking help from CBD with the advice of the doctor, he controlled his blood sugar levels and CBD helped him with diabetic retinotherapy. This confirmed that CBD has the potential to decrease oxidative stress on the circulatory and nervous system. The Harvard med school researcher in relation with time magazine reported that diabetic patients having CBD treatments notice normal insulin levels gradually.
Diabetes is an autoimmune disease; an issue inside the body that causes blood glucose (sugar) levels to ascend higher than typical. The American Diabetes Association describes Type 1 diabetes as the body’s failure to deliver insulin. Sort 2 diabetes is characterized as the body’s failure to utilize insulin properly, alluded to as insulin resistance.
According to a 2017 report by CDC,(1) in 2015 over 30 million people in the US alone suffered from diabetes – or approximately 9.5% of the total US population. Another estimated 7.2 million cases went undiagnosed.
The level of grown-ups with diabetes increments in more seasoned age gatherings, achieving a high of 25.2% among individuals matured 65+. 132,000 of the patients were kids and youths more youthful than the age of 18 (0.18% of the aggregate U.S. populace more youthful than age 18 years). 10.7 million individuals with analyzed diabetes, have a place with the 45-65 age gathering, while another 3.6 million cases in a similar age aggregate stayed unreported.
The CDC report also revealed a correlation between education level and occurrence of Type II diabetes. People with less than a high school education are diagnosed with diabetes at higher rates (12.6%) than the ones with high school (9.5%) or higher education (7.2%).
In 2015, diabetes was ranked as the seventh leading cause of death in the United States, accounting for more than 79,500 deaths nationwide.
Lab testing(2) on mice experiencing Type I diabetes has demonstrated that CBD can postpone irritation related to diabetes, bringing about the diminished frequency of beginning of the malady.
CBD’s calming and cell reinforcement properties can likewise make it compelling in relieving diabetes complexities.
Another examination done on rats, distributed in the American Journal of Medicine reasoned that CBD utilize was related with bringing down levels of fasting insulin and HOMA-IR, and littler midsection periphery among 2,544 members.(3)
CBD has demonstrated guarantee when utilized as a guide for kidney malady by blocking cytokines which cause aggravation in the kidneys. Likewise, CBD washes down the stomach related tract, diminishing nephrotoxicity caused by high blood glucose levels. As indicated by a recent report, 12 out of 15 kidney ailment patients demonstrated a decrease in the agony that is related with the kidney ailment in the wake of utilizing CBD items.
Research(4) has demonstrated that CBD can diminish neurotoxicity and irritation caused by high glucose levels, diminishing retinal aggravation, and shielding the retinal veins from swelling or spilling.
Cannabinoid receptors in the cardiovascular framework are critical in the direction of dissemination and heart work. Endocannabinoids (those created by the human body) and CBD, specifically, are enter in directing the invulnerable irritation framework and circulatory capacities. Irritation is firmly associated with atherosclerosis, so scientists propose the utilization of CBD may counter its belongings.
Cannabidiol or CBD regulatorily affects immune system ailments. That implies it can be utilized to alleviate atherosclerosis movement, particularly when the ailment is caused by high glucose levels, for example, in diabetes. Clinical investigations have shown that utilizing CBD to actuate CB2 receptors can diminish a few issues in the circulatory framework.